L-Methylfolate and Antidepressants: Can This Supplement Boost Your Treatment?

Updated March 7, 2025

Original article: January 6, 2008

I do a lot of psychopharmacology research — more than most people would consider normal. I try to share only the most interesting and relevant findings while sparing you the more technical details. But today, you’re in for a deeper dive.

This topic is too important to ignore, especially if you’re struggling with treatment-resistant depression.

What Is L-Methylfolate (MTHF)?

L-methylfolate (MTHF) is the biologically active form of folate, a B vitamin crucial for brain function and neurotransmitter production. Your body converts dietary folate into MTHF, but this process requires specific enzymes — and not everyone produces enough of them…