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Interest in complementary and alternative medicine (CAM) for bipolar disorder—acupuncture, omega-3 fatty acids, N-acetylcysteine (NAC), massage, homeopathy, naturopathy, hypnosis, etc.—has exploded on social media. But does any of it actually work? If you know me, you know that I look for medical evidence. Someone once attempted to insult me by saying that I would try heroin if it had clinical evidence. Um, yeah. Clinical evidence is what says something is safe and effective, so, yes, I would try it. (Of course, I don’t think heroin is going to pass that bar any time soon.) Here’s what the evidence says about CAM for bipolar disorder (spoiler: some adjuncts help depressive symptoms; others are all hype).