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Bipolar medication may work well for months or years and then seem to lose its effect. People often call this “medication tolerance” or say they have become “immune” to the drug. I know how frustrating this is. You’re going along, things seem to be fine, the medication is working, and then, bam, out of nowhere, an episode hits. Medication tolerance is one explanation, but there are others as well. Let’s take a look at medication tolerance evidence, mood episode recurrence, and the likelihood of you staying in remission.